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Yoshimi Takai Selected Research

Nectins

1/2022Nectin-2 in general and in the brain.
3/2018Roles of the third Ig-like domain of Necl-5/PVR and the fifth Ig-like domain of the PDGF receptor in its signaling.
1/2016Nectin spot: a novel type of nectin-mediated cell adhesion apparatus.
6/2013Interaction of Necl-4/CADM4 with ErbB3 and integrin α6 β4 and inhibition of ErbB2/ErbB3 signaling and hemidesmosome disassembly.
6/2013Nectin-like molecule-5 regulates intimal thickening after carotid artery ligation in mice.
4/2013Reduction of the ST6 β-galactosamide α-2,6-sialyltransferase 1 (ST6GAL1)-catalyzed sialylation of nectin-like molecule 2/cell adhesion molecule 1 and enhancement of ErbB2/ErbB3 signaling by microRNA-199a.
2/2012The cell adhesion gene PVRL3 is associated with congenital ocular defects.
10/2011Interaction of nectin-like molecule 2 with integrin alpha6beta4 and inhibition of disassembly of integrin alpha6beta4 from hemidesmosomes.
10/2010Cooperation of nectin-1 and nectin-3 is required for normal ameloblast function and crown shape development in mouse teeth.
5/2010Overexpression of Necl-5 correlates with unfavorable prognosis in patients with lung adenocarcinoma.
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Yoshimi Takai Research Topics

Disease

23Neoplasms (Cancer)
06/2022 - 12/2002
3Breast Neoplasms (Breast Cancer)
06/2022 - 12/2019
3Alzheimer Disease (Alzheimer's Disease)
11/2012 - 05/2009
3Infertility (Sterility)
09/2006 - 07/2002
3Carcinoma (Carcinomatosis)
03/2005 - 07/2003
2Intellectual Disability (Idiocy)
01/2023 - 01/2008
2Neoplasm Metastasis (Metastasis)
01/2021 - 12/2019
2Fibrosis (Cirrhosis)
07/2013 - 10/2009
2Kidney Diseases (Kidney Disease)
08/2011 - 12/2008
2Wounds and Injuries (Trauma)
01/2010 - 10/2009
2Herpes Zoster
06/2008 - 10/2003
2Warburg Sjo Fledelius syndrome
01/2008 - 03/2005
1Aphasia (Dysphasia)
01/2023
1Epilepsy (Aura)
01/2023
1Mental Disorders (Mental Disorder)
01/2022
1Inborn Genetic Diseases (Disease, Hereditary)
01/2016
1Double cortex
09/2015
1Tropical Spastic Paraparesis (Tropical Spastic Paraplegia)
03/2015
1T-Cell Leukemia (Leukemia, T Cell)
03/2015
1Adult T-Cell Leukemia-Lymphoma (Leukemia Lymphoma, T Cell, Acute, HTLV I Associated)
03/2015
1Inflammation (Inflammations)
11/2014
1Cardiovascular Diseases (Cardiovascular Disease)
10/2014
1Schizophrenia (Dementia Praecox)
12/2013
1Lung Neoplasms (Lung Cancer)
04/2013
1Hypoxia (Hypoxemia)
03/2013
1Colonic Neoplasms (Colon Cancer)
03/2013
1Pathologic Constriction (Stenosis)
01/2013
1Hydrocephalus (Hydrocephaly)
01/2013
1Ischemia
03/2012
1Genetic Translocation (Chromosomal Translocation)
02/2012
1Adenocarcinoma
10/2011
1Hypertension (High Blood Pressure)
08/2011
1Ectodermal Dysplasia (Aplasia Cutis Congenita)
10/2010
1Glomerulonephritis
01/2010
1Virus Diseases (Viral Diseases)
10/2009
1Type 1 Diabetes Mellitus (Autoimmune Diabetes)
10/2009
1Memory Disorders (Memory Loss)
05/2009
1Cysts
03/2009
1Chronic Renal Insufficiency
12/2008
1Albuminuria
12/2008
1Starvation
06/2008
1Martsolf syndrome
01/2008
1Infections
07/2007
1Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome)
07/2007

Drug/Important Bio-Agent (IBA)

24NectinsIBA
01/2022 - 06/2002
7poliovirus receptorIBA
03/2018 - 08/2004
6Proteins (Proteins, Gene)FDA Link
01/2021 - 05/2004
6Cell Adhesion MoleculesIBA
12/2019 - 01/2007
6Immunoglobulins (Immunoglobulin)IBA
03/2018 - 10/2005
4afadinIBA
09/2015 - 06/2008
3DNA (Deoxyribonucleic Acid)IBA
06/2022 - 12/2019
3LigandsIBA
01/2015 - 08/2009
3Amyloid Precursor Protein Secretases (beta-Secretase)IBA
11/2012 - 05/2009
3Cadherins (E-Cadherin)IBA
10/2009 - 06/2002
3Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
06/2007 - 10/2005
2Trastuzumab (Herceptin)FDA Link
06/2022 - 01/2021
2Oncogene Proteins (Oncogene Protein)IBA
03/2015 - 05/2004
2Messenger RNA (mRNA)IBA
04/2013 - 03/2013
2matrigelIBA
03/2012 - 03/2009
2IntegrinsIBA
10/2011 - 09/2010
2Laminin (Merosin)IBA
10/2011 - 09/2010
2AldosteroneIBA
08/2011 - 12/2008
2GTP Phosphohydrolases (GTPases)IBA
08/2011 - 12/2008
2Mineralocorticoid Receptors (Mineralocorticoid Receptor)IBA
08/2011 - 12/2008
2Tyrosine (L-Tyrosine)FDA Link
08/2009 - 03/2007
2Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA
08/2008 - 03/2007
2Integrin alphaVbeta3IBA
08/2008 - 06/2007
2GTPase-Activating Proteins (GTPase-Activating Protein)IBA
01/2008 - 03/2005
1rat Cnksr2 proteinIBA
01/2023
1SuspensionsIBA
06/2022
1Phosphoric Monoester Hydrolases (Phosphatases)IBA
01/2022
1Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
12/2019
1Phosphatidylinositols (Phosphatidylinositol)IBA
12/2019
1Chemokine ReceptorsIBA
01/2015
1CytokinesIBA
11/2014
1Soluble N-Ethylmaleimide-Sensitive Factor Attachment ProteinsIBA
10/2014
1Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
07/2013
1Angiotensin IIIBA
07/2013
1Cell Adhesion Molecule-1IBA
04/2013
13' Untranslated Regions (3' UTR)IBA
03/2013
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
03/2012
1Transcription Factors (Transcription Factor)IBA
08/2011
1SaltsIBA
08/2011
1SteroidsIBA
08/2011
1Monomeric GTP-Binding ProteinsIBA
08/2011
1Extracellular Matrix ProteinsIBA
09/2010
1Integrin alpha6beta4IBA
09/2010
1Glycoproteins (Glycoprotein)IBA
01/2010
1Peptides (Polypeptides)IBA
11/2009
1Amyloid beta-PeptidesIBA
11/2009
1class-I restricted T cell-associated moleculeIBA
10/2009
1Guanine Nucleotide Dissociation Inhibitors (GDIs)IBA
12/2008
1Fas Ligand Protein (Fas Ligand)IBA
06/2008
1CateninsIBA
06/2008
1Carrier Proteins (Binding Protein)IBA
06/2008
1ClaudinsIBA
06/2008
1Member 14 Tumor Necrosis Factor ReceptorsIBA
07/2007
1Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
03/2007

Therapy/Procedure

1Heterologous Transplantation (Xenotransplantation)
01/2015
1Therapeutics
07/2007